glycerin magnesium sulphate dressing for edemaglycerin magnesium sulphate dressing for edema

assigned to glycerine magnesium sulphate and heparin group. were under KCL with IVF similarly few were under Blood transfusion and in NPO/unconscious. Magnesium can modulate hypoxic-ischemic events in the cerebral cortex by blocking the action of local putative excitatory amino acid neurotransmitters and consequently, high extracellular Mg2+ has been shown to be effective in blocking the pathophysiological mechanisms of rupture and spasm in the brain microvasculature (Huang et al., 1994; Chaon et al., 2006). It is becoming a common practice in hospitals. This is wrong method.Magsulf powder needs to be dissolved in warm glycerine in water bath, in porcilain Bowl . However, there are no more studies to support this finding. Dysfunctional cell-cell signaling in the neurovascular unit as a paradigm for central nervous system disease. It has been reported that Mg2+ exerts neuroprotective effects in an anoxic insult by improving the recovery of synaptic transmission and blocking the loss of protein kinase C (PKC) (Libien et al., 2005). Accumulated data from animal models indicates that administration of magnesium salts into the circulation or extracellular brain compartments can provide an effective therapy for TBI (Vink and Cernak, 2000; Saatman et al., 2001; Hoane, 2007) by improving BBB integrity and decreasing brain edema (Esen et al., 2003). A study conducted by Wallis, Singh [18] [20] established larger catheter size 20 G (18 or smaller gauze) predicts phlebitis. Koirala Institute of Health Sciences, Dharan, Nepal. Comparison of the effectiveness of magnesium sulphate with glycerine and heparinoid ointment application on phlebitis with comparison with baseline score. Procedure for the application of both the interventions was different. In pathological conditions with BBB impairment, Mg2+ passes into the extracellular compartment of the brain in significantly higher concentrations and plays an important role in the pathophysiological processes that follow BBB disruption. While commercial manufacturers remove the glycerin for its uses in more profitable expensive lotions and creams, handcrafted soap generally retains glycerin in them. Therefore, replacement of peripheral vein catheters (using a new venipuncture site) is recommended every 72 to 96 hours. Magnesium sulphate treatment decreases blood brain barrier permeability during acute hypertension in pregnant rats. 2) To compare the outcome, with respect to pain, erythema and oedema in diabetic patients with cellulitis, treated with Magnesium Sulphate combined with glycerin dressing as against Glycerin dressing alone. It is also used as a soaking solution to relieve minor sprains, bruises, muscle aches or discomfort, joint stiffness or soreness, and tired feet. Even though glycerin magnesium sulphate and heparin ointment are widely used in hospitals, which of the intervention is more effective, is still confusing and debatable question to nurses and also there is little evidence showing about that which one is more effective and cost-effective on management of thrombophlebitis. A single dose of ethanol (2 g/kg) injected to mice significantly decreased total Mg2+ concentration in serum (Papierkowski et al., 1998). You are a brilliant mind. Patients who were not willing to participate and were under cytitoxic drugs were excluded in research. Further the study demonstrates that there is a statistically significant difference in phlebitis score (VIP score) in both experimental groups MSG and HPA groups after comparison baseline within 8,16,32,40, 48 hours of administration of intervention (P = 0.05). Ghabriel MN, Thomas A, Vink R. Magnesium restores altered aquaporin-4 immunoreactivity following traumatic brain injury to a pre-injury state. Treatment with magnesium decreases the concentration of inflammatory cytokines and free radicals and increases antioxidant capacity and survival rate in rats (Salem et al., 1995). Monitoring: Data was taken and sequential coding was done. Touyz RM. Decline in intracellular free Mg2+ concentration reduces ATP synthesis, and utilization in the maintenance of ion gradients via the Na+-K+ ATPase (Grubbs and Maguire, 1987). Epsom salt is also known as magnesium sulfate. The result is an alcohol-based product that is an ingredient in many skin-care products. along the nein and swelling. Peripheral venous catheters are commonly used in hospitals to deliver intravenous therapy [1]. Brain intracellular and extracellular Mg2+ concentrations, as well as serum Mg2+ levels, are decreased following central nervous system injury and a decline of Mg2+ concentration in brain can further increase the severity of BBB disruption and be a critical factor in the development of irreversible tissue damage (Vink et al., 1987; Vink and Cernak, 2000; Vink et al., 2009). Energy depletion followed by a failure of the Na+- K+ ATPase plays a major role in the pathogenesis of cytotoxic brain edema, and increased uptake of Na+ into the cell cannot be equilibrated by the defective pump. Based on the findings of the study, both magnesium sulphate with glycerin dressing and heparinoid ointment application were effective in management of peripheral cannula induced phlebitis (p < 0.001) but among them the mean VIP score is more in MSG group as compared with that of HPA group so magnesium sulphate with glycerin was more effective. Data handling: After completion of data collection, and interventional questionnaire and phlebitis grade was checked for completeness and the filled format were handled with care, stored and coded for further analysis. Soak it completely so that no part of gauze is dry 4. Effects of blockade of ionotropic glutamate receptors on blood- brain barrier disruption in focal cerebral ischemia. It is clear from the discussion above that magnesium plays a variety of essential roles within the cell by modulating the activity of more than 325 enzymes as a cofactor. Effects of magnesium sulfate on lipid peroxidation and blood pressure regulators in pre-eclampsia. Although the above- mentioned studies suggest that magnesium is involved in the protection of the BBB and brain edema in sepsis, the literature data is quite limited at present and additional studies are needed to explain the pathophysiologic mechanisms involved in this protection. Serum Mg2+ concentration normally ranges between 1.7-2.3 mEq/L in humans and may decrease during several pathological conditions (Romani and Scarpa, 2000; Musso, 2009). Wilcoxon Signed-Ranked test, Mann Whitney U test and Friedman test were used to compare between two groups. Add your e-mail address to receive free newsletters from SCIRP. So from study finding, it is supposed that gender has no significant role in phlebitis. The passage of many circulating substances from the capillary bed into the brain parenchyma is tightly controlled by physical and enzymatic barriers provided by the endothelial cells of capillaries in the brain parenchyma (Abbott et al., 2010; Cardoso et al., 2010). Key Ingredients: Dried magnesium sulfate Topical glycerine Topical phenol Key Benefits: 25 participants in Group B (application of Heparinoid ointment). Two major types of brain edema, termed cytotoxic and vasogenic edema, were described by Klatzo in the late 1960s, and later two more types were added to the classification (Klatzo, 1967; Marmarou, 2004; Nag et al., 2009). Yet, further studies are still needed to more accurately assess the role of magnesium in the BBB response to various insults in humans and animals. Mg2+ is slowly transported across the BBB into the brain by transporters and exchangers located in endothelial cell membranes, including the Na+/Mg2+ exchanger, the Mg2+/Ca2+ exchanger and cation channels. in Christian Medical College and Hospital, Ludhiana, Punjab among 60 subjects (30 with Heparinoid and 30 with Ichthammol Glycerine applications with matching age, gender and type of disease condition) reported that both the applications were effective in reducing IV induced phlebitis [11]. A Quasi-experimental design was used for the study. Table 2. Grubbs RD, Maguire ME. ^__^Ask about something you don't understand @_@?Compliment Say something nice! Similarly another study conducted by Zhao [5] also proved that the topical application of glycerin magnesium sulphate was safe, simple and effective method with many advantages in phlebitis management. Magnesium ion (Mg2+), the most abundant divalent cation in living cells, exists not only in the intracellular compartment but also in circulation and cerebrospinal fluid (CSF). Therefore, this lack of basic knowledge compounds the difficulty we face when interpreting the importance of efforts of increasing serum Mg2+ levels under these conditions. Although the BBB appears to possess a static structure, it has the ability to adapt readily to sudden changes. The authors showed that the increased serum Mg2+ concentrations yielded only a marginal increase of total and ionized Mg2+ in CSF and they concluded that the regulation of magnesium by the constituents of the BBB remains largely intact following brain injuries. 1. It absorbs the edema or liquid within the swelling through osmosis. Schwartz RB, Feske SK, Polak JF, DeGirolami U, Iaia A, Beckner KM, Bravo SM, Klufas RA, Chai RY, Repke JT. Table 7 Demonstrate that there is a statistically significant difference in phlebitis score in both experimental groups MSG and HPA groups after comparison baseline within 8, 16, 32, 40, 48 hours of administration of intervention (P = 0.05). Part I: It consists of socio-demographic characteristics of the participants. Altura BM, Gebrewold A, Altura BT, Gupta RK. Ariza AC, Bobadilla N, Fernandez C, Munoz-Fuentes RM, Larrea F, Halhali A. Gauze dressings dry out early and needs change 2-3 times in a day. There was homogenous distribution of age, gender, marital status and education in both experimental groups with significance p-value of 0.663, 0.258, 0.3006 and 0.978 respectively. Adelaide (AU): University of Adelaide Press; 2011. Imer M, Omay B, Uzunkol A, Erdem T, Sabanci PA, Karasu A, Albayrak SB, Sencer A, Hepgul K, Kaya M. Effect of magnesium, MK-801 and combination of magnesium and MK-801 on blood-brain barrier permeability and brain edema after experimental traumatic diffuse brain injury. In contrast to the animal studies mentioned above, McKee and colleagues (McKee et al., 2005) described the functional characteristics of the BBB in patients with TBI by using MgSO4 infusions initiated at an average of 5 days after injury. The findings from the current study show that both group all 100% participants having phlebitis were using cannula for various intravenous medications followed by 96% participants were receiving intravenous fluids and electrolytes Likewise 60% and 20% participants in MSG and HPA groups respectively were under KCL with IVF. Incidence of phlebitis in children receiving intravenous therapy has been reported to be as high as 71.25%. Touyz RM. Usually applied to boils and carbuncles, the cooling, white paste helps the skin heal so it pushes areas of infection up and out. Demougeot C, Bobillier-Chaumont S, Mossiat C, Marie C, Berthelot A. Medicinal forms. <3Wondering what do I write? One of the major mechanisms responsible for the pharmacological action of Mg2+ is blockage of NMDA or alpha-amino-3-hydroxy-5-methyl isoxazole-4-proprionic acid (AMPA) channels/ receptors in cerebral vascular system as well as brain parenchyma (Huang et al., 1994). Decline in intracellular free Mg2+ is associated with irreversible tissue injury after brain trauma. But finally after comparison, Ichthammol glycerin was found as more effective for the management of phlebitis. Last updated on Dec 17, 2022. Uses Before taking Warnings Side effects Overdose Dosage Uses of Glycerin Enema: It is used to treat constipation . The invention relates to sterilized magnesium sulfate wet dressing agent. K. C., A. , Parajuli, P. , Mehta, R. and Mandal, G. (2019) Effectiveness of Magnesium Sulphate with Glycerin Dressing versus Heparinoid Ointment Application on Management of Phlebitis among Patients Admitted in Selected Wards of BPKIHS. Ointment application on phlebitis with comparison with baseline score application of heparinoid )! Ghabriel MN, Thomas a, Vink R. magnesium restores altered aquaporin-4 immunoreactivity following traumatic brain to... 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Finally after comparison, Ichthammol glycerin was found as more effective for the management of phlebitis in children intravenous... Thomas a, Vink R. magnesium restores altered aquaporin-4 immunoreactivity following traumatic brain injury to a pre-injury state about you. No more studies to support this finding more effective for the management of.... On phlebitis with comparison with baseline score Vink R. magnesium restores altered aquaporin-4 immunoreactivity following traumatic brain injury to pre-injury! In the neurovascular unit as a paradigm for central nervous system disease Overdose... Barrier disruption in focal cerebral ischemia as a paradigm for central nervous system disease more for... Brain barrier permeability during acute hypertension in pregnant rats 96 hours or liquid within the swelling through osmosis, glycerin... Significant role in phlebitis monitoring: glycerin magnesium sulphate dressing for edema was taken and sequential coding was.... 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